Overcoming Challenges in Membrane Protein Research

In the realm of biological research, the study of membrane proteins has long been a formidable challenge due to their intricate nature and crucial role in various cellular processes. These proteins, embedded within the lipid bilayer, play pivotal roles in cellular communication, transport, and signaling. However, the very same lipid environment that grants them their…

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Extracellular Vesicle Analysis: Size, Concentration, and Zeta Potential

The particle size, concentration, and Zeta potential of extracellular vesicles (EVs) are crucial parameters reflecting their biophysical characteristics and biological functions. The size of EVs depends on the originating cells, carriers, and biogenesis pathways, ranging in diameter from 30nm to 150nm. The concentration of EVs varies from a few to thousands per milliliter, depending on…

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The Protein Powering Human Development

Nibrin (NIPBL) is a protein encoded by the NIPBL gene in humans. This protein plays a crucial role in Notch signaling, a fundamental cellular signaling pathway involved in cell-cell communication, which influences a wide array of developmental processes. The Notch pathway is known to guide binary cell fate decisions in the course of embryonic development…

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